Director: David Silverman
After Homer accidentally pollutes the town's water supply, Springfield is encased in a gigantic dome by the EPA and the Simpsons are declared fugitives.
Dan Castellaneta
as Homer Simpson / Itchy / Barney / Abe Simpson / Stage Manager / Krusty the Clown / Mayor Quimby / Mayor's Aide / Multi-Eyed Squirrel / Panicky Man / Sideshow Mel / Mr. Teeny / EPA Official / Kissing Cop / Bear / Boy on Phone / NSA Worker / Officer / Santa's Little Helper / Squeaky-Voiced Teen (voice)
Julie Kavner
as Marge Simpson / Selma Bouvier / Patty Bouvier (voice)
Nancy Cartwright
as Bart Simpson / Maggie Simpson / Ralph / Nelson / Todd Flanders / TV Daughter / Woman on Phone (voice)
Yeardley Smith
as Lisa Simpson (voice)
Hank Azaria
as Professor Frink / Comic Book Guy / Moe / Chief Wiggum / Lou / Carl / Cletus / Bumblebee Man / Male EPA Worker / Dome Depot Announcer / Kissing Cop / Carnival Barker / Counter Man / Apu / Drederick Tatum / Sea Captain / EPA Passenger / Robot / Dr. Nick / Wise Guy (voice)
Harry Shearer
as Scratchy / Mr. Burns / Rev. Lovejoy / Ned Flanders / Lenny / Skull / President Arnold Schwarzenegger / Kent Brockman / Principal Skinner / Dr. Hibbert / Smithers / Toll Booth Man / Guard / Otto / Kang (voice)
Pamela Hayden
as Milhouse Van Houten / Jimbo Jones / Rod Flanders (voice)
Tress MacNeille
as Sweet Old Lady / Colin / Mrs. Skinner / Nelson's Mother / Pig / Cat Lady / Female EPA Worker / G.P.S. Woman / Cookie Kwan / Lindsey Naegle / TV Son / Medicine Woman / Girl on Phone (voice)
Albert Brooks
as Russ Cargill (voice)
Karl Wiedergott
as Man / EPA Driver (voice)
Marcia Wallace
as Edna Krabappel (voice)
Russi Taylor
as Martin Prince (voice)
Maggie Roswell
as Helen Lovejoy (voice)
Phil Rosenthal
as TV Dad (voice)
Billie Joe Armstrong
as Billie Joe Armstrong (voice)
Mike Dirnt
as Mike Dirnt (voice)
Tré Cool
as Tre Cool (voice)
Joe Mantegna
as Fat Tony (voice)
Tom Hanks
as Tom Hanks (voice)
